A veteran-owned and operated Small Business … a company whose mission is to "Translate Regenerative Medicine Product Concepts to Patient Care".

  Scientific Publications​

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1. Basu J, (2014). An Organ regeneration platform for industrial production of hollow neo-organs. In "Regenerative Medicine and Tissue Engineering", Intech Open Publishers, Editor: Daniel Eberli, In Press.

2. Basu J, AAd B, Bertram TA, Rao N (2014). Preclinical safety evaluation of cell based therapeutic products: an emerging global perspective. Toxicologica Pathology, In Press.

3. Basu J, Ludlow JW (2014). Cell-based therapeutic products: potency assay development and application. Regenerative Medicine, 9: 497-512

4. Lei Y, Basu J, Zhang J (2014). Fabrication of myocardial patch with cells differentiated from human induced pluripotent cells. Methods in Molecular Biology, In Press.

5. Basu J, Rivera EA, Bertram TA (2014). Regenerative medicine of the gastro-intestinal tract. Toxicologic Pathology, 41: 82-90

​6. Bruce AT, Ilagan RM, Sangha N, Spencer T, Guthrie KI, Rivera EA, Kelley RW, Jain D, Basu J. (2014).  Selected regenerative renal cells attenuate disease progression in rodent models of chronic kidney disease through inhibition of NFkB pathways and enhancement of tubular cell proliferation. Tissue Engineering Part A.
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7. Rivera EA, Jayo MJ. (2013).  Histological Evaluation of Tissue Regeneration Using Biodegradable Scaffold Seeded by Autologous Cells for Tubular/Hollow Organ Applications.  Methods Mol Biol. 2013; 1001:353-74.

8. Guthrie KI, Bruce A, Sangha N, Rivera EA and Basu J (2013). Potency evaluation of tissue engineered and regenerative medicine products. Trends in Biotechnology, 31: 505-514
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​9.  Basu J, Mihalko KL, Rivera EA, Guthrie KI, Genheimer CW, Sangha N, Ludlow JW (2013). Tissue engineering of esophagus and small intestine in rodent injury models. Methods in Molecular Biology 1001: 311-24

10. Guthrie KI, Sangha N, Genheimer CW, Basu J, Ludlow W (2013). Migration assay to evaluate cellular interactions with biomaterials for tissue engineering medicine applications. Methods in Molecular Biology 1001: 189-96

11. Ludlow JW, Basu J, Genheimer CW, Guthrie KI, Sangha N (2013). Isolation of pulsatile cell bodies from esophageal tissue. Methods in Molecular Biology 1001: 35-42
 12. Serban MA, Knight T, Payne R, Basu J, Rivera E, Robbins N, McCoy D, Halberstadt C, Jain D, Bertram TA (2013). Crosslinked gelatin microspheres with continuously tunable degradation profiles for renal tissue regeneration. Biotechnology and Applied Biochemistry, doi:10.1002/bab.1125
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13. Knight T, Basu J, Rivera EA, Spencer T, Jain D, Payne R (2013). Fabrication of a multi-layer 3D scaffold with controlled porous micro-architecture for application in small intestine tissue engineering. Cell Adhesion and Migration 7, 267-274

14. Bertram TA, Basu J, and Ludlow JW. The Digestive Tract. 3rd Edition, Handbook of Toxicology Pathology, Editors WM Haschek-Holk, CG Rousseaux, MA Wallis. Elsevier Publishers

15. Basu J, Ludlow JW. Developmental engineering the kidney: leveraging morphogenic principles for renal regeneration. Birth Defects Research Part C-Embryo Today, 96(1): 30-38

16. Basu J, Ludlow JW (Editors). Organ Regeneration, Methods in Molecular Biology. Humana Press, 2013.
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17. Basu J, Mihalko K, Payne R, Rivera EA, Knight T, Genheimer C, Guthrie K, Sangha N, Jayo M, Jain D, Bertram T, Ludlow J (2011). Regeneration of de novo esophageal tissue in a rodent model following adipose derived smooth muscle cell/PGA/PLGA construct implantation. Medical Hypotheses 78(2): 231-4.

18. Basu J, Mihalko K, Payne R, Knight T, Rivera EA, Jayo MJ, Genheimer C, Guthrie KI, Sangha N, Ludlow JW (2011). Regeneration of rodent small intestine tissue following implantation of scaffolds seeded with a novel source of smooth muscle cells. Regenerative Medicine 6(6): 721-731

19. Basu J, Ilagan R, Guthrie KI, Sangha N, Genheimer C, Quinlan S, Payne R, Rapoport S, Knight T, Rivera EA, Jain D, Jayo MJ, Bertram TA, Ludlow JW (2012). Regeneration of native-like neo-urinary tissue from non-bladder cell sources. Tissue Engineering Part A, 18: 1025-34
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20. Basu J, Genheimer CW, Rivera EA, Payne R, Mihalko K, Guthrie K, Bruce AT, Robbins N, McCoy D, Sangha N, Ilagan R, Knight T, Spencer T, Wagner BJ, Jayo MJ, Jain D, Ludlow JW, Halberstadt C (2011). Functional evaluation of primary renal cell/biomaterial Neo-Kidney Augment prototypes for renal tissue engineering. Cell Transplantation, 20: 1771-90

21. Presnell SC, Bruce AT, Wallace SM, Choudhury S, Genheimer CW, Cox B, Guthrie K, Werdin ES, Tatsumi-Ficht P, Ilagan RM, Kelley RW, Rivera EA, Ludlow JW, Wagner BJ, Jayo MJ, Bertram TA.  Isolation, Characterization, and Expansion Methods for Defined Primary Renal Cell Populations from Rodent, Canine, and Human Normal and Diseased Kidneys. Tissue Eng Part C Methods. 2010 Oct 27.
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22. Kelley R, Werdin ES, Bruce AT, Choudhury S, Wallace SM, Ilagan RM, Cox BR, Tatsumi-Ficht P, Rivera EA, Spencer T, Scott Rappaport H, Wagner BJ, Guthrie K, Jayo MJ, Bertram TA, Presnell SC.   Tubular cell-enriched subpopulation of primary renal cells improves survival and augments kidney function in rodent model of chronic kidney disease.   Am J Physiol Renal Physiol. 2010 Nov; 299 (5): F1026-39. Epub 2010 Sep 8.
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23. Cruise GM, Rivera EA, Jones RM, Vestal M, Virmani R, Ding YH, Kallmes DF.   A comparison of experimental aneurysm occlusion determination by angiography, scanning electron microscopy, MICROFIL perfusion, and histology.  J Biomed Mater Res B Appl Biomater. 2009 Nov; 91(2): 669-78.
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24. Ishii Y, Sakamoto S, Kronengold RT, Virmani R, Rivera EA, Goldman SM, Prechtel EJ, Hill JG, Damiano RJ Jr. A novel bioengineered small-caliber vascular graft incorporating heparin and sirolimus: excellent 6-month patency.   J Thorac Cardiovasc Surg. 2008 Jun; 135(6):1237-45; discussion 1245-6. Epub 2008 May 23

25. Jayo MJ, Jain D, Ludlow JW, Payne R, Wagner BJ, McLorie G, Bertram TA. Long-term durability, tissue regeneration and neo-organ growth during skeletal maturation with a neo-bladder augmentation construct. Regen Med. 2008; 3(5):671-82.

26. Jayo MJ, Jain D, Wagner BJ, Bertram TA. Early cellular and stromal responses in regeneration versus repair of a mammalian bladder using autologous cell and biodegradable scaffold technolgies. J Urol. 2008; 180(1):392-397.

27. Jayo MJ, Watson DD, Wagner BJ, Bertram TA. Tissue engineering and regenerative medicine: role of toxicologic pathologist for an emerging medical technology. Toxicol Pathol. 2008; 36(1):92-6.

28. Davis VL, Jayo MJ, Ho A, Kotlarczyk MP, Hardy ML, Foster WG, Hughes CL. Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erB2. Cancer Res. 2008; 68(20):8377-83.

29. Ishii Y, Kronengold RT, Virmani R, Rivera EA, Goldman SM, Prechtel EJ, Schuessler RB, Damiano RJ Jr.   Novel bioengineered small caliber vascular graft with excellent one-month patency.   Ann Thorac Surg. 2007 Feb; 83(2): 517-25.

30. Kipshidze N, Sadzaglishvili K, Panarella M, Rivera EA, Virmani R, Leon MB.  Evaluation of a novel endoluminal vascular occlusion device in a porcine model: early and late follow-up. J Endovasc There. 2005 Aug; 12(4): 486-94.
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31. Waksman R, Fournadjiev J, Baffour R, Pakala R, Hellinga D, Leborne L, Yazdi H, Cheneau E, Wolfram R, Seabron R, Horton K, Kolodgie F, Virmani R, Rivera EA.  Transepicardial autologous bone marrow-derived mononuclear cell therapy in a porcine model of chronically infracted myocardium. Cardiocasic Radiat Med.  2004 Jul-Sep; 5(3):125-31.



POSTERS:
​ 1. Basu J, Guthrie K, Rivera E, Deepak J, Bertram, T (ISSCR Connect series webinar, May 2014). The Big Bucket: What does it really take to turn your favorite cell population into a commercially successful product?
 2. Bivalacqua T, Steinberg G, Smith N Lerner S, Bochner B, Lee C, Rivera E, Jain D, Bertram T, Schoenberg M. Preclinical Translation of Tissue Engineered Neo-Urinary Conduit Using Derived Smooth Muscle Cells for Urinary Reconstruction. (2014) EAU, Stockholm, Sweden.

3. Rivera EA,Basu J, Bruce A, Guthrie K, Kelley R, Robertson A, Bertram T (2013). Clinical translation of a tissue engineered urinary diversion using a biodegradable scaffold seeded with adiposederived smooth muscle cells. 2013 Stem Cell Event Trilogy, Royal College of Pathologists, London, UK.

​4. Jain D, Basu J, Payne R, Rivera EA and Bertram T (2013). Regeneration of Hollow Organs: Translation from Pre-Clinical Models to the Clinic. TERMIS-AP, Shanghai

5. Payne R, Knight T, Basu J, Rivera E, Mihalko K, Robbins N, McCoy D, Jayo M, Halberstadt C, Jain D (2013). Animal models for biomaterials screening and neo-kidney augment prototype evaluation in the kidney. Society for Biomaterials Annual Meeting, Boston MA
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6. Basu J, Payne R, Rivera E, Robbins N, McCoy D, Knight T, Sangha N, Guthrie K, Genheimer C, Jain D, Ludlow JW, Halberstadt C. Regenerating kidney structure and functionality: bio-response of rodent models of renal disease to implantation of neo-kidney augment prototypes composed of selected renal cells and biomaterials. International Society for Stem Cell Research (ISSCR) 2012 Conference, Yokohama, Japan.
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7. Basu J, Payne R, Rivera E, Robbins N, McCoy D, Knight T, Sangha N, Guthrie K, Genheimer C, Jain D, Ludlow JW, Halberstadt C. Bioresponse of a rodent hemi-nephrectomy model to implantation of Neo-Kidney Augment prototypes composed of selected renal cells and biomaterials. CTS-IXA 2011 International Congress, Miami, October 2011.
 8. Basu J, Halberstadt C, Rivera E, Jayo M, Serban M, Knight T, Payne R, Robbins N, McCoy D, Guthrie K, Sangha N, Genheimer C, Ludlow J, Presnell S, Bertram T. Kidney tissue regeneration catalyzed by a Neo-Kidney Augment product composed of selected renal cells and biomaterials. Tissue Engineering International and Regenerative Medicine Society (TERMIS-NA), December 2011.

9. Serban MA, Knight T, Payne R, Basu J, Rivera EA, Robbins N, McCoy D, Halberstadt C, Jain D, Bertram TA. Fabrication of chemically cross-linked gelatin microspheres with tunable degradation profiles. Society for Biomaterials, April 2011.
​ 10. Knight T, Payne R, Basu J, Ludlow JW, Sangha N, Guthrie K, Jayo M, Rivera E, Jain D. Evaluation of biomaterials for esophagus or small intestine tissue engineering. Society for Biomaterials, April 2011.

11. Payne R, Knight T, Basu J, Rivera E, Robbins N, McCoy D, Jayo M, Halberstadt C, Jain D. Bioresponse of mammalian kidney to implantation of polymeric biomaterials. Society for Biomaterials, April 2011.

12. Ludlow JW, Rivera E, Payne R, Knight T, Sangha N, Genheimer CW, Guthrie KI, Jayo MJ, Jain D, Basu J. Esophageal tissue engineering using an organ regeneration platform technology. TERMIS-NA, December 2010 (www.tengion.com/pdfs/Ludlow-2010-TERMIS-Eso-poster-Final.pdf).

13. Basu J, Ludlow JW, Rivera E, Payne R, Knight T, Sangha N, Genheimer CW, Guthrie KI, Jayo MJ, Jain D. Tissue engineering of small intestines using a neo-urinary organ regeneration technology. TERMIS-NA, December 2010 (www.tengion.com/pdfs/Ludlow-2010-TERMIS-SI-poster-FINAL.pdf.

14. Basu J, Rivera E, Genheimer CW, Robbins N, Payne R, McCoy D, Guthrie KI, Sangha N, Knight T, Jayo M, Ludlow JW, Jain D, Halberstadt C. Mammalian kidney nephrogenic response to primary renal cell/biomaterial-based Neo-Kidney Augment. TERMIS-NA, December 2010(www.tengion.com/pdfs/Ludlow-2010-TERMIS-SI-poster-FINAL.pdf).

15. Basu J, Payne R, Rivera E, Robbins N, McCoy D, Knight T, Jayo MJ, Jain D, Halberstadt CR. In vivo evaluation of biomaterials in mammalian kidney. TERMIS-NA, December 2010. (www.tengion.com/pdfs/Basu-2010-TERMIS-Biomaterials-poster-FINAL.pdf).

16. Manuel J Jayo, Elias A. Rivera, Wendy Sharp, Belinda J Wagner, John W Ludlow, Deepak Jain, Timothy A Bertram. Regeneration of Native-Like Mucocutaneous Region at the Skin-Conduit Junction Following Neo-Urinary Conduit™ Implantation.  Tengion Inc., Winston-Salem, North Carolina, USA
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17. Joydeep Basu, Kelly Guthrie, Roger Ilagan, Namrata Sangha, Christopher Genheimer, Sarah Quinlan, Richard Payne, Scott Rapoport, Toyin Knight, Belinda J. Wagner, Elias A. Rivera, Manuel J. Jayo, Deepak Jain, Timothy A. Bertram and John W. Ludlow.  Functional de novo Neo-Urinary Conduit from Porcine Peripheral Blood and Adipose-derived Smooth Muscle Cells Tengion Inc., Winston-Salem, North Carolina, USA
 18. Presnell SC, Bruce AT, Wallace SM, Choudhury S, Genheimer CW, Cox B, Guthrie K, Werdin ES, Tatsumi-Ficht P, Ilagan RM, Kelley RW, Rivera EA, Ludlow JW, Wagner BJ, Jayo MJ, Bertram TA.  Isolation and characterization of Bioresponsive Renal Cells from Human And Large Mammal with Chronic Kidney Disease. Tengion, Inc., Science & Technology, Winston-Salem, NC
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​19. Joydeep Basu, Richard Payne, Elias A. Rivera, Neil Robbins, Darell McCoy, Toyin Knight, Manuel J Jayo, Deepak Jain, and Craig R Halberstadt.  Enhanced Renal function in Dynamic 3D Culture System. Tengion, Inc., Science & Technology, Winston-Salem, NC